Adsorption of Methylene Blue and Tetracycline by Zeolites Immobilized on a PBAT Electrospun Membrane.
David Picón 1 2, Alicia Vergara-Rubio 2 3, Santiago Estevez-Areco 4, Silvina Cerveny 5 6, Silvia Goyanes 1 2
https://pubmed.ncbi.nlm.nih.gov/36615274/
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Natural Zeolite Clinoptilolite Application in Wastewater Treatment: Methylene Blue, Zinc and Cadmium Abatement Tests and Kinetic Studies.

Melodj Dosa, Nadia Grifasi, Camilla Galletti, Debora Fino, Marco Piumetti
https://pubmed.ncbi.nlm.nih.gov/36431678/

Commentary:

-“Clinoptilolite exhibited the best adsorption capacities at 100 ppm: the abatement reached 98% (t = 15 min). Both Clinoptilolite and Activated Charcoal, at 250 ppm, exhibited the same adsorption capacities, namely, 96%. Finally, at 250 ppm MB (Methylene Blue), the adsorption capacity of Clinoptilolite was analyzed with the copresence of Zn2+ and Cd2+ (10 ppm), and the adsorption capacities were compared with those of Activated Charcoal. The results showed that both adsorbents achieved 100% MB abatement (t = 40 min)."

-the 2nd half of this quote shows a general trend investigated in studies with clinoptilolite zeolite, that Clinoptilolite improves its binding capacity when paired with other nontoxic minerals. As is done in HCS products.
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Metachromasy as an indicator of photostabilization of methylene blue adsorbed to clays and minerals.

Maya Samuels, Omer Mor, Giora Rytwo
https://pubmed.ncbi.nlm.nih.gov/23474529/

Commentary:
-“The influence of methylene blue adsorption to different clays on its photodegradation was studied. Methylene blue in solution was decomposed by sunlight in a *zero-order process. Adsorption to some clay minerals (sepiolite and vermiculite) and a zeolite (clinoptilolite) accelerated the degradation process, and converted it to a *first-order reaction. On the other hand, adsorption to other clay minerals (palygorskite and montmorillonite) stabilized the dye and prevented its degradation."

-*Zero order: a constant amount of drug is eliminated per unit time.

-*First order kinetics occur when a constant proportion of the drug is eliminated per unit time. So in first order reactions, or kinetics, more is eliminated or degraded per unit of time if more of the substance is in solution or in an organism.
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Hydroxychloroquine Adsorption in Aqueous Medium Using Clinoptilolite Zeolite

https://pubmed.ncbi.nlm.nih.gov/35875406/

Commentary:
-“The ecotoxicological tests with Artemia salina and Lactuca Sativa proved that the final effluent did not show toxicity after the adsorption treatment. Based on the results obtained in this work, clinoptilolite zeolite is a potential adsorbent for reducing HCQ toxicity in aquatic matrices.”


Contraindications Avoid Methylene Blue in combination with the following drugs, treatments, supplements, or conditions:

• In general, don't take Methylene blue with other food, supplement, or medications.

• Nobody Should Ever Take Over 5mg per KG of Bodyweight. There is no need to take over 2mg per KG of Bodyweight.

​​

• Do not... combine with Hyperbatic Oxygen Chamber Therapy

• Don't take if you are on any SSRI Medication or Any Serotonergic Drug (Serotonin is a Stress-induced compound)

• Don't take if you have been diagnosed or tested positive for: 
  -Heinz Body Anemia
  -G6PD deficiency

Dangerous Drug Interactions

• 5-HTP

• Vyvanse (lisdexamfetamine)

• Wellbutrin XL (bupropion)

• Norco (acetaminophen/hydrocodone)

• alfentanil, fentanyl;

• buspirone;

• digoxin, digitalis;

• dihydroergotamine, ergotamine;

• phenytoin;

• pimozide;

• quinidine;

• warfarin (Coumadin, Jantoven);

• an MAO inhibitor–isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, and others;

• an “SSRI” antidepressant–citalopram, escitalopram, fluoxetine, paroxetine, sertraline, Prozac, Paxil, Zoloft, and others;

• an “SNRI” antidepressant–desvenlafaxine, duloxetine, levomilnacipran, milnacipran, venlafaxine, Effexor, Cymbalta, Pristiq, and others;

• other antidepressants–bupropion, clomipramine, mirtazapine; or

• Medicine to prevent organ transplant rejection–cyclosporine, sirolimus, tacrolimus.