Methylene Blue + Ubiquinol/PQQ
Youthing With Mitochondria Power Players
Miracle Mitochondrial Magic: Methylene Blue
A Synthetic Dye Used In Human Medicine for 140 Years
Non Affiliate Link: https://cztl.bz/
Directly Heal Your Mitochondria With Methylene Blue
(CLICK HERE)
It is not a Pharmaceutical.
It was synthesized prior the Flexner Report
and the Rockefeller Takeover of US Education
Take It In Water, Enough Water to Dilute the Taste
-Beware of Purity. Only Buy USP Grade.
-Powder is Much Cheaper. Dilute with Distilled Water To Make a 1% Solution. See This Video (Click Here)
-Demand a Certificate of Analysis (COA) and check for Heavy Metals.
-Warning: This product is often made cheaply and filled with heavy metals.
What is Methylene Blue? Methylene blue is an inexpensive blue dye developed by scientists in 1872 for the textile industry. In addition to being a brilliant blue dye for fabric, surprisingly, it was soon discovered to be useful in the scientific laboratory and in medicine. As a stain, it could help scientists see bacteria, parasites, yeasts, and other microorganisms when looking under a microscope.
By adding the blue dye to microorganisms on an imaging plate, the internal structures and tiny organelles are illuminated and more easily seen by scientists. Remarkably, methylene blue is such a reliable stain that scientists still use it today in laboratories worldwide. But a stain for microscopy is only the tip of the iceberg as far as what methylene blue can do for science and the world. - Mark Sloane
Top 10 Uses of Methylene Blue as listed in Mark Sloan's Book: "The Ultimate Guide To Methylene Blue"
1. An Antidote for Chemical Poisoning and Overdose
2. The Greatest Anti-Malarial
3. Methylene Blue: The Virus Warrior
4. Forget Dementia: MB for Alzheimer’s and Parkinson’s
5. Cognitive Enhancement: A Brain-Boosting Powerhouse
6. Depression No More
7. Hope for Autism?
8. The Great Pain Reliever
9. A Healthier Heart
10. Methylene Blue vs. Cancer
DOSAGE
Start with 10 drops am and pm
work up to the Daily Protocol
Contraindications
Avoid Methylene Blue in combination with the following drugs, treatments, supplements, or conditions:
In general, take Methylene blue without any other food, supplement, or medication.
Do not... combine with Hyperbatic Oxygen Chamber Therapy
Don't take if you are on any SSRI Medication or Any Serotonergic Drug (Serotonin is a Stress Hormone)
Don't take if you have been diagnosed or tested positive for:
-Heinz Body Anemia
-G6PD deficiencyNobody Should Ever Take Over 5mg per KG of Bodyweight. There is no need to take over 2mg per KG of Bodyweight.
5-HTP
Vyvanse (lisdexamfetamine)
Wellbutrin XL (bupropion)
Norco (acetaminophen/hydrocodone)
alfentanil, fentanyl;
buspirone;
digoxin, digitalis;
dihydroergotamine, ergotamine;
phenytoin;
pimozide;
quinidine;
warfarin (Coumadin, Jantoven);
an MAO inhibitor–isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, and others;
an “SSRI” antidepressant–citalopram, escitalopram, fluoxetine, paroxetine, sertraline, Prozac, Paxil, Zoloft, and others;
an “SNRI” antidepressant–desvenlafaxine, duloxetine, levomilnacipran, milnacipran, venlafaxine, Effexor, Cymbalta, Pristiq, and others;
other antidepressants–bupropion, clomipramine, mirtazapine; or
Medicine to prevent organ transplant rejection–cyclosporine, sirolimus, tacrolimus.
To Stack with Methylene Blue: Ubiquinol + PQQ
Non Affiliate Link (CLICK HERE)
Dosage = One pill 1to 7 times a week.
Use your intuition.
Remember... mitochondria always need more help nowadays.
You will literally grow more mitochondria on this protocol.
Loop your orin and cut your dose to save money.
I'll be quoting from the article (Click Here):
Three-Step Strategy to Reverse Mitochondrial Aging
By Michael Downey, Health & Wellness Author.
UBIQUINAL is a far more potent CoQ10
Coenzyme Q10 Protects Mitochondria
Scientists have established that coenzyme Q10 (CoQ10) is an essential nutrient for normal mitochondrial function (namely, the production and transfer of energy).28-30 When CoQ10 levels fall, mitochondrial dysfunction skyrockets.28 Studies have found that boosting CoQ10 levels via supplementation increases mitochondrial electron transport—whether the cells are deficient in CoQ10 or not.29,30
CoQ10’s ability to protect the vital mitochondria helps put an end to the vicious cycle that underscores a critical aspect of pathological aging. In fact, research with laboratory models has suggested that CoQ10 may be one of our most potent anti-aging nutrients. Studies have found that when cells or organisms are deficient in CoQ10, mitochondrial oxidative stress increases and aging is accelerated.28,31 However, supplementation triggers a significant slowing down of the aging process and an extended life span.32,33
One study showed that rats supplemented with CoQ10 experience a 24% increase in maximum life span and an 11.7% increase in average life span.34 In human terms, based on today’s life expectancy of 78.5 years, this mean increase translates to a more than 9-year increase in life span!35
CoQ10 also seems to work via a multi-targeted set of epigenetic mechanisms that not only slow aging—but that also protect against a variety of mitochondria-related diseases.36-38 Epigenetic mechanisms involve changes in gene function that do not relate to changes in gene structure.39 Studies have shown that CoQ10 protects against neurodegenerative diseases40-42 and mental health disorders,43 enhances lung function,44,45 guards against the effects of elevated glucose in diabetes and metabolic syndrome,46-48 and offers impressive defense against cardiovascular disease, one of the primary diseases of aging.49-51
Animal studies demonstrate that supplementation with CoQ10 reduces oxidative stress and reduces the buildup of amyloid-beta plaque (associated with Alzheimer’s disease)40-42,52,53 —resulting in a significant improvement in cognitive performance and memory.53
In human studies, 4 weeks to 6 months of CoQ10 supplementation at 60-300 milligrams a day was shown to improve cardiac systolic function and ejection fraction.49,50 One study showed that 8 weeks of CoQ10 supplementation at 300 milligrams a day improved heart-muscle systolic function by enhancing both mitochondrial performance and endothelial function.50 And in a 5-year, randomized, double-blind, placebo-controlled trial among elderly individuals, CoQ10 combined with selenium slashed the death rate from cardiovascular disease by more than half!54 In fact, the authors of one study recognized CoQ10 as a “scientific breakthrough in the management of chronic heart failure.”55
CoQ10 offers a powerful way to help slow—or even reverse—a natural aging process by restoring youthful mitochondrial protection from free radicals.27,56
COQ10: POTENTIAL THERAPY FOR INHERITED MITOCHONDRIAL DISORDER
Newly released research underscores the vital importance of coenzyme Q10 (CoQ10) to mitochondrial health.
A study released ahead of print in April 2013 by the journal Mitochondrion has found that patients with mitochondrial DNA depletion syndrome (MDS) have significantly deficient levels of CoQ10.85 MDS is a hereditary condition characterized by grossly reduced cellular levels of mitochrondrial DNA in infancy. MDS involves various progressive disorders that are often fatal in childhood.86
Currently, there are no effective therapies available for MDS86—but this recent finding indicates that CoQ10 could represent a candidate therapy for this condition.
The suggestion that CoQ10 may constitute a therapeutic hope for treating this serious mitochondrial-deficiency disorder demonstrates just how powerfully CoQ10 protects mitochondria.
This also underscores CoQ10’s vital importance in slowing or reversing the “natural” aging process in healthy individuals.
PQQ Creates New Mitochondria
While coenzyme Q10 optimizes mitochondrial function and protects them from free radical damage, scientists have found another coenzyme that triggers the creation of new mitochondria altogether.
A huge research advance in 2012 showed that the coenzyme pyrroloquinoline quinone (or PQQ) activates genes that induce mitochondrial biogenesis—the spontaneous formation of new mitochondria in aging cells!57
This represents a major breakthrough in battling the mitochondrial destruction that underlies aging.
PQQ deficiency has a profound effect on your genes—especially those involved in cellular stress, cell signaling, transport of metabolites, and of course, the creation of new mitochondria.57 Specifically, PQQ deficiency negatively affects the expression pattern of 438 genes—but research has found that this effect is reversed after supplementation with PQQ.57
Prior to this breakthrough, some of the only scientifically validated ways to reliably stimulate the creation of new mitochondria were sustained calorie restriction or strenuous physical activity—both of which are too rigorous and impractical for most aging people.58,59 PQQ now provides the most practical means of reversing the deadly decline in functional mitochondria that is the underlying cause of premature aging and degenerative disease.
Earlier findings repeatedly indicated PQQ’s central role as a potent growth factor.60,61 In preclinical trials, when animals were deprived of dietary PQQ, they exhibited stunted growth, impaired conception rates, and most importantly, fewer mitochondria.62-64 However, re-introducing PQQ into the diet reversed these effects—while simultaneously increasing mitochondrial number and energetic efficiency.62,63
Like CoQ10, PQQ also actively supports the energy transfer within the mitochondria that supplies the body with most of its bioenergy. Its exceptional stability allows it to carry out thousands of these transfers without undergoing molecular breakdown. PQQ has been proven especially effective in neutralizing two of the most potent free radicals, the superoxide and hydroxyl radicals.65
5,000 Times More Effective than Vitamin C!
Research demonstrates that PQQ is 30 to 5,000 times more efficient at reducing oxidation than other common antioxidants such as vitamin C.60
In a revealing 2010 study, scientists reported that similar protection of mitochondrial function that is seen with some other compounds (such as quercetin, hydroxytyrosol, and resveratrol) at high dietary concentrations measured in millimoles occurs with PQQ at dietary concentrations measured in nanomoles.66 In other words, it takes a million times more of these other compounds to have a mitochondria-protective effect equivalent to PQQ!
The revelation of its ability to favorably affect system-wide cell development, metabolism, and mitochondrial biogenesis helps explain the wealth of data on PQQ’s neuroprotective and cardioprotective benefits.
PQQ has now been shown to block the development of abnormal proteins linked with neurodegenerative diseases. For example, it prevents cellular damage and demise due to accumulation of amyloid beta protein associated with Alzheimer’s disease,67,68 and of the alpha-synuclein protein that is associated with Parkinson’s disease.57,69
In humans, supplementation with 20 milligrams a day of PQQ significantly improved cognitive function in middle-aged and elderly people. These results were amplified when the subjects also took 300 milligrams per day of CoQ10.70
In animal studies, researchers investigating its impact on cardiovascular disease have demonstrated that PQQ reduces the size of the heart area damaged by acute heart attack and favorably decreases lipid peroxidation.71 PQQ also helps heart muscle cells resist acute oxidative stress—specifically by preserving and enhancing mitochondrial function.72
Neither humans nor the bacteria that colonize the human digestive tract have demonstrated the ability to synthesize PQQ,73 which has led researchers to classify it as an essential micronutrient. This means that the body can’t make enough of it for good health—and that supplementation is essential.74
UBIQUINOL PROVIDES SUPERIOR BIOAVAILABILITY
Called a “coenzyme” because of its unique ability to participate in chemical reactions but remain at steady-state levels in the cell, coenzyme Q10 plays a central role in energy metabolism.28-30
CoQ10’s ability to cycle back and forth between ubiquinone and ubiquinol accounts for many of its unique properties. Ubiquinol, with its ability to scavenge free radicals, is an electron donor, while ubiquinone is an electron acceptor. This remarkable ability to cyclically accept and donate electrons, as well as to effect complementary chemical reactions in the mitochondria, accounts for CoQ10’s unparalleled value to almost all life forms.
The chemical difference between ubiquinone and ubiquinol is that the ubiquinol compound contains two hydroxyl groups. These two hydroxyl groups enable ubiquinol to be more easily dissolved into water than ubiquinone, thus making it easier to assimilate, which helps explain why it is so much more bioavailable than ubiquinone.
In a side-by-side single-dose human study, ubiquinol absorption was compared directly to conventional CoQ10 (ubiquinone) using the same delivery system. Subjects were given either 100 mg of ubiquinol or 100 mg of ubiquinone. The findings showed that in aged test subjects, ubiquinol absorption was 60% greater in this single-dose side-by-side comparison.87
A review of published studies on human subjects reveals that it requires very high doses of ubiquinone CoQ10 to achieve the same levels attainable with modest amounts of ubiquinol CoQ10.88-92 Clinical studies using 1,200 and 2,400 mg per day of ubiquinone achieved CoQ10 blood levels similar to 150 and 300 mg per day respectively of ubiquinol.88-91
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